INDAZOLE-3-CARBOXYLIC ACID

PRODUCT IDENTIFICATION
CAS NO. 4498-67-3

INDAZOLE-3-CARBOXYLIC ACID

EINECS NO. 224-794-5
FORMULA C8H6N2O2
MOL WT. 162.15

H.S. CODE

  

TOXICITY

  
SYNONYMS 1H-Indazole-3-carboxylic acid; 1,2-Benzodiazole-3-carboxylic acid;
1,2-Benzopyrazole-3-carboxylic acid; ácido 1H-indazol-3-carboxílico; Acide 1H-indazole-3-carboxylique;
DERIVATION

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE off-white to yellowish powder
MELTING POINT

266 - 270 C

BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER  

SOLVENT SOLUBILITY

  
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

  
AUTOIGNITION

 

NFPA RATINGS Health: 1; Flammability: 0; Reactivity: 0
FLASH POINT  
STABILITY

Stable under ordinary conditions.

APPLICATIONS
Indazole is another name of benzopyrazole which has the pyrazole ring (five-membered unsaturated ring structure composed of three carbon atoms and two nitrogen atoms at 1,2 positions) fused to benzene ring. Indole is the compound that pyrrole (haing one nitrogen atom) is fused to benzene ring. There are tautomerer of indole. They are called indolenine (unsubstituted 3H-indole) The structural isome of indole is called isoindole. Indoline is dihydroindole. Benzimidazole is the compound that imidazole ring (containing two nitrogen atoms at nonadjacent positions) is fused to benzene. These structure compounds are important in agrochemical industry. They are fundamental structures of  fungicides, herbicides, and plant growth regulators. These compounds are used in the production of amino acids, perfumes, colorants, and medicines. Indazole class compounds can be applied in the field that photodynamic activity is needed. An example of end product from indazole-3-carboxylic acid is granisetron, an antiemetic agent.

Granisetron is an antiemetic agent to prevent the nausea and vomiting in conjunction with cancer chemotherapy or with radiation therapy, by blocking 5-HT3 receptors without effect on other receptors such as dopamine D2 receptor and 5-HT4 receptor. The hydrochloride salt of granisetron is a white to off-white crystalline powder; soluble in water and saline; administered intravenously. Chemical designation is endo-N-(9-methyl-9- azabicyclo [3.3.1] non-3-yl)-1-methyl-1H- indazole-3-carboxamide hydrochloride. Ondansetron is another 5-HT3 receptors antagonist  used as an antiemetic or antinauseant. The chemical designation is 2,3-dihydro (or 1,2,3,9-tetrahydro)-9-methyl-3-[(2-methyl-1H-imidazol-1-yl) methyl]- 4H-carbazol-4-one. The medicinal actions of granisetron and ondansetron are almost same. Alosetron, 2,3,4,5-tetrahydro-5- methyl- 2-[ (5-methyl-1H- imidazol-4-yl) methyl]-1H-pyrido[4,3-b] indol-1-one, is an 5-HT3 receptor also, but it is used in the treatment of diarrhea-predominant (IBS-D).

SALES SPECIFICATION

APPEARANCE

 off-white to yellowish powder

ASSAY

98.0% min

MELTING POINT

266 - 270 C
TRANSPORTATION
PACKING

 

HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XI, Risk Phrases: 36/37/38, Safety Phrases: 26-36